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Another example of the interconnection of body systems is neuropathy (nerve damage outside the brain and spinal cord), which is often caused by diabetes, which in turn is linked to metabolic disorders

Tirzepatide targets both GLP-1 and another incretin receptor called GIP

Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion

Further studies with larger sample sizes and direct comparative analyses are warranted to clarify relative efficacy and confirm translational relevance

The combination supports investigations into endocrine pathway regulation and growth hormone signaling mechanisms

Liraglutide weight loss clinical trials Semaglutide is another GLP-1 product developed by Novo Nordisk with a better weight loss effect than liraglutide