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Triple agonists like retatrutide add GIP and glucagon agonism to GLP-1 effects

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The initial selection was done using the Students t -test and was based on a binary comparison (genes significantly different between LPS + BSO and LPS alone were selected)

REFERENCES United Nations Office on Drugs and Crime

These shifts happen because GLP-1 signaling dampens the release of hunger hormones like ghrelin while boosting satiety signals from cholecystokinin and peptide YY