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Wang W, Zhang J, Zhang Q, Wan S, Zhu X, Zhang Q, et al
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Conversely, it is activated when AMP and/or fructose 2,6-bisphosphate concentrations increase, indicating a low energy charge
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Similar results were obtained by Casado-Vela et al
While erastin (an inhibitor of the cystineglutamate antiporter system Xc) was senolytic in SK-MEL-103 cells and BSO (a sulfoximine derivative that reduces levels of glutathione) in IMR90 cells, only the three GPX4 inhibitors tested showed senolytic activity in all senescent models tested (Extended Data Fig
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