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21 Moreover, extracellular lactate-induced H3K18la in T helper 17 (Th17) cells, a subset of CD4 + T helper cells secreting IL-17, contributes to transforming pro-inflammatory T cells into Treg cells

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The specific mechanisms by which elevated homocysteine contributes to cardiovascular pathologies and whether interventions to lower homocysteine levels are beneficial remain areas of debate and investigation