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The sequence of the BH3 peptides has been previously reported 93,94

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doi: 10.1016/j.biomaterials.2017.03.034 240 IshiharaMNishidaYKitanoSKawaiAMuraokaDMomoseFet al

Since then, the idea of liver cirrhosis as a condition of IGF-I deficiency during adult age has been yearly consolidated from a number of publications establishing the origin of this lack from a decrease in GH receptors seen in cirrhotic livers[216] and a progressive reduction of liver synthesis capability from decreased hepatocellular mass in advanced stages[209]

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Thus, -glucan and BCG can induce M polarization toward M1 M through the interplay and interaction between epigenetic reprogramming and cellular metabolic reprogramming to enhance anti-infectious immunity