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If approved, it would represent another step-change in outcomes comparable to what tirzepatide was to semaglutide
Also, bacterial metabolites, such as SCFA and indole, a product of bacterial tryptophan metabolism involved in interbacterial communication, exert direct signaling actions on colonic L cells (19)
However, one of the most healing agents for the gut is the amino acid glutamine because it is the major fuel source for the enteroendocrine cells
Additionally, the significant weight loss achieved with GLP-1 receptor agonists leads to changes in body composition, fluid distribution, and metabolic rate, all of which can influence cardiovascular hemodynamics
GLP-1 binds to the GLP-1 receptor (GLP-1R)