Centre for Innovation in Regulatory Science (CIRS), London, UK
2E) but was 20-fold less potent (CS EC 50 = 2.1 M, Table S2), suggesting that further potency improvements would be required
Botulinum Toxin Type A that is now used in cosmetic clinics today is purified to a very high level and is injected in controlled and tiny doses
For brand companies, the AG decision is a balance: deploying an AG captures revenue during the exclusivity window but potentially reduces the settlement value they can extract from first-filers who will accept earlier entry in exchange for no-AG commitments
Its ability to enhance neuronal survival, promote neurogenesis, keep memory, and facilitate memory synaptogenesis contributes to slowing down or reversing the cognitive decline associated with this devastating condition
doi: 10.1371/journal.pone.0026358 581 AdamowiczJLCaikauskaiteIFriedbergF