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Preclinical studies have indicated that GLP1RAs, such as tirzepatide, may directly impact the vasculature by enhancing endothelial function and decreasing inflammation, which are important in preventing atherosclerosis[30]

[8] It is also available as the fixed-dose combinations of sitagliptin/metformin (Janumet, Janumet XR) [8] and sitagliptin/simvastatin (Juvisync)

This may be managed with well-fitted walking shoes that cushion the feet and redistribute pressure

GLP-1 side effects doctors want you to know While GLP-1s can be game-changers when it comes to treating insulin resistance, regulating blood sugar and helping people achieve significant weight loss, they're not without risk of side effects

Lee CJ, Sears CL, Maruthur N

FAQ How much weight can I lose with a medical weight loss program