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Indeed, global GSH depletion in mice has been shown to cause rapid weight loss and death within 2 weeks, whereas liver-specific GSH depletion does not result in such systemic toxicity, despite the liver being the primary site of GSH synthesis (12)

Ozempic is approved for type 2 diabetes, not obesity, and off-label prescribing for weight loss is generally not recommended by Swedish authorities

This pharmacological profile creates a dose-dependent weight loss curve that, in clinical trials, reached 24.2% at the 12mg weekly dose over 48 weeks and an astonishing 28.7% at 12mg over 68 weeks in the TRIUMPH-4 phase 3 trial

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However, leptin has never been found to be effective in treating obesity, or even in individuals that have insufficient leptin (2)

This article was co-authored by Andrea Rudominer, MD, MPH