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Safety and efficacy for human use have not been established through adequate and well-controlled studies

GL, JY, LL, YT, HW, BL, LD, JT and YC were involved in drafting the manuscript

The latest generation of obesity drugs might have another potential benefit: improving fertility in men

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One of the most critical innovations is the development of long-acting GLP-1 receptor agonists, where molecular modifications have extended drug half-life to nearly 7 days, enabling once-weekly dosing and improving patient adherence rates beyond 80%