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By combining the actions of both GLP-1 and GIP, Tirzepatide enhances insulin secretion and reduces glucagon release

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This consultation confirms that disease activity is stable, current DMT regimens are working effectively, and the patient has no contraindications such as severe nutritional deficiency, swallowing disorders, or active disease relapse

ukasik J, Salminen S, Szajewska H

Both agonists cause conformational changes of the salt bridge pair E124 3.33 and R283 6.55 and the aromatic cluster W276 6.48 , F279 6.51 , H280 6.52 , and F312 7.42 , which may, in turn, lead to GHSR activation