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Mannella, 1997

GHSR is predominantly expressed in the pituitary gland and hypothalamus and may be present in different tissues and organs, such as the thyroid gland, pancreas, spleen, myocardium, and adrenal gland (45)

This confirms the mechanism relies entirely on vagal afferent GLP-1R signaling

Similarly the "one-size-fits-all" approach to dosing is also often wrong - like saying everyone needs exactly the same amount of anaesthetic agents, insulin, or even the same number of beers

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The SGLT2 inhibitors (SGLTis) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) effectively reduce HbA1c, but via very different mechanisms, making them an effective duet for combination therapy