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Targeting ASBT can increase the contact time, thus extending the interaction time between drugs and the intestinal epithelium, thereby enabling the utilization of transporter-mediated endocytosis and resulting in improved oral uptake of peptides [51]
This early benefit reflects the direct vascular effects of GLP-1 receptor activation
Moreover, TZD inhibited the function of Th17 cells, enabling them to modulate the Th17/Treg balance to treat AR
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