Recent Advancements in the AUD Pipeline:- On August 29, 2025: Eli Lilly and Company initiated a proof-of-concept study evaluating mazdutide in participants diagnosed with Alcohol Use Disorder
For patients I see in clinic, retatrutide may potentially be a highly impactful future tool to treat their obesity and transform their health trajectory. Commenting on the topline results, Professor Graham Finlayson, chair in psychobiology at the University of Leeds, said it was striking to see retatrutide reaching the weight loss range historically associated with bariatric surgery and that the headline efficacy results are impressive, particularly the proportion of participants reported to achieve very large weight losses. He added: In principle, that broader pharmacology could produce larger effects on body weight and metabolism, although the full peer-reviewed data will be needed to understand the balance between efficacy, tolerability and discontinuation. While this clinical trial did not examine weight regain after stopping retatrutide, other studies have found that discontinuing weight-loss medications such as semaglutide and liraglutide typically results in near-total weight regain within about 18 months
Vial vs Pen: Which Format Does Retatrutide Currently Use
Serena Williams suggests GLP-1s could aid athletes
Consequently, NAPQI remains unmetabolized, resulting in toxicity
This hormone helps to regulate blood sugar levels and also plays a role in appetite control
