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Discovery of BMS-986318, a potent nonbile acid FXR agonist for the treatment of nonalcoholic steatohepatitis

According to DSM-5 criteria,[] a patient is required to fulfill all the three primary criteria (exposure to the dopamine-blocking agent, severe muscle rigidity, and fever) and at least two other measures (diaphoresis, dysphagia, tremor, incontinence, altered level of consciousness, mutism, tachycardia, elevated or labile blood pressure, leukocytosis, and elevated creatine phosphokinase)