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In severe cases, even reducing 25 events per hour may still leave a patient with significant OSA

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Authors contributions ROM, RC and RCLAC contributed equally to the literature review and elaboration of this manuscript

Baseline patient characteristics, full frequencies of side effects and study structure are not described in detail

In studies of myocardial reperfusion injury, it has been found that, in the early stages of reperfusion, moderately increased ROS can activate STAT3 phosphorylation, which then translocates to the mitochondria and nucleus, thereby alleviating cytosolic calcium overload during ischemia/reperfusion (I/R) injury [259, 260]