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Recent employer surveys found: 59% reported utilization exceeding expectations 66% reported a significant impact on prescription drug spending Some employers reported annual GLP-1 spending growth of 3050% As demand increases, organizations are seeking ways to manage access while maintaining support for employees who may benefit from treatment

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Exercise as a Secondary Metabolic Stressor Adipose tissue dysfunction in obesity promotes the release of small extracellular vesicles enriched with oxidatively stressed mitochondrial components [66, 91], reflecting unresolved mitochondrial strain