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Amylin acts in the central nervous system to increase sympathetic nerve activity

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Despite this, it was removed from the market in the late 1970s because of its high risk of lactic acidosis ( Various in vitro and in vivo studies performed in different types of tumors, highlighted the ability of phenformin to reduce cancer cell proliferation strongly than metformin ( Up to now, only one study demonstrated the ability of phenformin to reduce cell viability in TC cells

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Also, several studies lacked full disclosure of variance measures or raw data, preventing the inclusion of potentially relevant findings