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5-Hydroxytryptophan, the precursor to serotonin, is an ideal supplement for low serotonin levels in DS given its low rate of adverse effects compared with selective serotonin reuptake inhibitors

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This susceptibility is compounded by impaired redox homeostasis and multiple pathogenic factors: i) dysfunctional protein clearance mechanisms involving PTEN-induced kinase 1 (PINK1), Parkin, and -synuclein proteostasis

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doi:10.1093/emboj/18.5.1321