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Succinate Modulation of Immune Functions As discussed in detail in the Metabolic Alterations Associated with Cancer page, and briefly above, increased levels of succinate in the cytosol result in the inhibition of the PHD enzymes that hydroxylate, and thereby destabilize, the HIF-1 subunit of the HIF-1 transcription factor complex
J Steroid Biochem Mol Biol 2025;249:106701
In a 2006 study, Kohrt found that women who lost about 10 pounds through six months of cardio exercise also lost more bone than women who didn't lose weight, even though their weight loss was mostly fat, not muscle
Hair loss was reported more frequently in patients with a greater weight loss (20%) suggesting that the events of hair loss were potentially related to the magnitude of weight loss
These findings are sometimes misdiagnosed as Reye syndrome especially in the circumstance where there has been a prior infection
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