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A major defect in cross-regulation involves defective function of regulatory T cells (Treg), often associated with gene variants such as FOXP3 and IL2RA that prevent suppression of this autoimmune cascade [59,60,61,62]

Lancet 402 , 529544 (2023)

Individuals with greater subcutaneous and visceral belly fat experience a reduction in brain volume during midlife, particularly in areas associated with cognition, memory, and executive processes, such as the temporal lobe [214]

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doi: 10.1155/2010/386545 34 MorahanB