Weight loss is associated with a decrease in PsO severity and improved quality of life (QoL).41,42 Weight loss greater than 5% is associated with a higher rate of minimum disease activity in patients who are obese or overweight and in treatment for PsO.43,44 The Mediterranean diet, which facilitates weight loss, reduces psoriatic lesions.45 Weight loss in patients with HS leads to a notable decrease in the number of lesions and, in some cases, disease remission.46 Dysfunctional adiposity has been associated with worse indices of CVR and Dermatology Quality of Life Index (DLQI) in patients with HS.47 The decrease in fatty tissue is associated with a decrease in molecular mechanisms that characterize the systemic inflammatory state.48 Diet and exercise are the first therapeutic step but these interventions are, however, often insufficient to achieve favorable outcomes in skin diseases, good response to treatment for these conditions, and a decrease in CVR

Additionally, sustained weight loss through treatments like tirzepatide can lead to decreased blood pressure and improved cholesterol levels, significantly reducing cardiovascular risks, including heart attack, stroke, and peripheral artery disease
Gruessner, R
With the right approach, you can effectively manage this side effect and continue your journey towards better health and well-being
What is the mechanism behind GLP-1's effect on reward pathways
Safety Considerations and Contraindications When used under the supervision of qualified professionals, semaglutide is generally considered safe