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The STEP 8 trial: direct comparison The STEP 8 trial is the most important study for this comparison because it pitted semaglutide 2.4 mg weekly directly against liraglutide 3.0 mg daily in adults with overweight or obesity but without diabetes

Both have limited data in severe hepatic impairment

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A single 10mg vial reconstituted all at once cannot safely last 12 weeks

For post-cholecystectomy patients with unpredictable bile flow patterns, oral dosing may offer psychological reassurance even if clinical differences are minimal