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As such, the association with efficacy may be the result of enhanced trafficking of the protein within the cell that ultimately modulates the cell surface abundance of the receptor, rather than the result of alterations in the receptor protein structure that may influence ligand affinity

Additionally, a lower platelet cytochrome c oxidase activity is associated with sepsis mortality [65] (that frequently take place in the presence of cardiac dysfunction)

La participacin de la prdida de peso en los efectos del tratamiento con LIRA en el programa SCALE es variable, encontrndose en torno al 100% en resultados sobre fracciones lipdicas, presin arterial e ndice apnea-hipopnea y alrededor del 30% en los efectos sobre el metabolismo hidrocarbonado, en probable relacin con el efecto incretnico del frmaco20

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