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Furthermore, these central effects may involve recruitment of pathways that are normally involved in stress and immune regulation, including adrenergic and opioid signaling and blocking either signaling pathway in rodent models again blunts the immunosuppressive effects of GLP-1RA, but this remains an area of active research as it whether this is also the case in humans

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Crossing the bloodbrain barrier: recent advances in drug delivery to the brain

Lancet (1965) 2(7409):4156

L.MassonG.BesenbacherS.SulemP.MagnussonG.et al (2012)

GLP-1 RAs consistently improved composite (secondary) renal outcomes in the CVOTs, principally driven by a reduction in new-onset albuminuria