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Li SD, Zhu YP, Zhang TT, Hang YY, Chen Q, Jin YL

At a glance Composition: TB4 fragment Ac-LKKTETQ (1723) Claimed actions track TB4s actin/repair biology, but evidence is largely analytical/detection and preclinical, not approved clinical therapy

This mechanism underlies its anesthetic, analgesic, and antidepressant properties

Mitochondria need NAD+ to function

The strongest evidence remains in topical applications, while injectable GHK-Cu should be viewed as an investigational compound with unknown safety profiles

According to the FDAs brief , the concern was whether the stability of the peptide would hold during manufacturing and how much the quality of the compounded product could change as a result