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[DOI] [PMC free article] [PubMed] [Google Scholar] 214.Murphy MB, Blashki D, Buchanan RM, Fan D, De Rosa E, Shah RN, et al

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For example, one experimental study showed that lutein reduced the ROS and SA--gal levels and upregulated the expression of heme oxygenase 1 (HO-1) and NAD(P)H quinone dehydrogenase 1 and downregulated the p53p21 pathway in H 2 O 2 -induced ARPE-19 cells [50]