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This dose level also showed the greatest total fat mass reduction in the body composition substudy, with participants losing an average of 21.6kg of pure fat mass compared to placebo

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This approach requires no sophisticated engineering, is fully compatible with standard mammalian expression systems, and yields high levels of the desired complex (Supplementary Fig

Given the FoxO1 ablation induced -cell dedifferentiation and caused hyperglycemia under physiologic stress 22 , we determined whether LOsG/ROS stresses decrease FoxO1 expression and thus induce -cell dedifferentiation