Artifactual oxidation to GSSG of 515% of the GSH found in a sample can occur during deproteination of biological samples with any of the commonly used acids, with consequent marked overestimation of GSSG
In vitro studies are preferrable but rely on having a biorelevant system that can representatively simulate the physiological conditions associated with this specific drug delivery process
Metformin also has modest effects on weight, typically resulting in small reductions or weight stabilisation rather than significant loss
Beta cell apoptosis, quantified by co-staining for TUNEL and the beta cell marker NKX6.1, was highest in new-onset mice, and approximately doubled compared with 12-week-old mice
That sensitivity determines when male pattern baldness begins. DHT and follicle miniaturization DHT gradually reduces follicle size in genetically susceptible individuals
A free radical is an unstable molecule that tries to steal electrons from other molecules, thus causing damage