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Yes, there are medications like GLP-1 receptor agonists that can increase GLP-1 activity and are used to treat type 2 diabetes

Unlike the injectables, it requires daily dosing with strict timing instructions

The interaction between DNA methylation and histone modifications, two major epigenetic mechanisms, also has adverse effects on child health outcomes

Unlike recombinant GH therapy, sermorelin has not been strongly associated with severe fluid retention, insulin resistance, or joint pain in the short term, though long-term data are limited

Regulatory environment (external): Active uncertainty - FDA's April 2026 proposal to restrict 503B compounding remains open for public comment through June 29, 2026

Peer review Peer review information Nature Reviews Drug Discovery thanks the anonymous reviewers for their contribution to the peer review of this work