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If managing type 2 diabetes, GLP-1s are typically continued long-term to maintain blood sugar control and reduce cardiovascular risks

DOI: 10.1016/S0026-0495(00)80077-3 9

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Rapid metabolic changes: The speed of weight loss on semaglutide often outpaces the body's ability to adapt

SGLT2-i reduces both systolic blood pressure (SBP) and diastolic blood pressure (DBP) across multiple trials and meta-analyses with reductions up to 8.6/4.3 mmHg, depending on the agent, dose and population studied