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The specific upstream triggers of each disease (such as A, ischemia and hemorrhage) activate these common downstream pathological processes, which in turn are the direct upstream activators of the core ferroptosis machinery (iron overload, lipid peroxidation and antioxidant system depletion)

Factors such as decreased mobility, nutritional status, and mitochondrial function decline are all contributors to sarcopenia [75]

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The findings are expected to ensure greater validity of the broader research outcomes, which may inform urban planning and design, public health strategies, and social policies aimed at improving the quality of life for older adults

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