Patient reports suggest some people notice increased cramping when moving to higher doses, particularly when advancing to 7.5mg or 10mg
3.0 3.1 Onakpoya IJ, Heneghan CJ, Aronson JK (2016)
Pregnant or breastfeeding individuals, and anyone with a history of seizures or active cancer, should consult a provider before considering it
Diastolic blood pressure reductions tend to be smaller, reinforcing the importance of continuing guideline-directed antihypertensive treatment
Tirzepatide Brand names include Mounjaro and Zepbound
On the basis of these findings, the overall efficacy and safety of tirzepatide has been investigated in the SURPASS clinical trial programme in comparison with placebo and other glucose-lowering medications including GLP-1 RAs and basal insulin [11]