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Nevertheless, various stimuli such as chronic disease states, metabolic conditions (e.g., type 2 diabetes mellitus [T2DM], obesity, dyslipidemia), smoking, and disturbed blood flow can disrupt such a quiescent phenotype and lead to endothelial cell dysfunction (ECD) (Fig

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However, they may experience a direct or acute penile injury in the future, which would result in a severe Peyronies indication

Now, for the administration itself

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