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This high cost, along with limited manufacturing supply, means usage has remained mostly concentrated in wealthier countries (notably the US and parts of Europe) and among patients who can afford to pay
In rare cases, the increase in skin cells may be caused by medications, cancer, or other medical conditions
Part of the reason is that they are so much cheaper than the real thing: Hims & Hers offers compounded semaglutide at a starting rate of $199 a montha sliver of the price of Wegovy, which can cost up to $1,350 a month
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Variants in the intronic or flanking regions of the genes directly involved in the thiopurine pathway were correlated with unfavorable treatment response, but the functional impact of the variants was unclear (Matimba et al., 2014)