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A commenter recommended an implementation strategy that encourages gradual participation and performance improvement while ensuring fairness

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These commenters emphasized that covered entities that do not submit data to the repository could be considered to be in violation of the Conditions of Participation and could be subject to a range of actions up to and including termination of their provider agreements

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Interestingly, we observed that the cecal microbiome of previously-obese animals returned to the lean state through NNMTi treatment and LD switch was distinct from the cecal microbiome of continuously lean control animals