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They took genetic samples from the microbiomes of healthy adults, young infants, and patients with inflammatory bowel disease (IBD) and searched for the gene that produces bilirubin reductase

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Clinical and experimental evidence confirms a U-shaped relationship between copper levels and blood pressure, indicating that both copper deficiency and excess are associated with a higher prevalence of hypertension [213]

There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH