doi: 10.1016/j.freeradbiomed.2022.01.020
Lactate can enter the intermembrane space of the mitochondria where it is oxidized to pyruvate, and in the process reducing NAD+ to NADH
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Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor
Nat Commun (2021) 12(1):2244
When this signaling pathway is antagonized, the protooncogene transcription coactivator YAP will be upregulated, leading to an increase in the key ferroptosis factors ACSL4 and TFRC, thereby inducing ferroptosis in cancer cells [88]
