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Oral semaglutide has been studied in PIONEER 6 (designed as a non-inferiority trials), with a mean follow-up of 1.3 years and positive results for the primary endpoint: the MACE rate was reduced by 21% but did not achieve statistically significant differences

J Neurosci 23:33943406 Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, Murphy TH (2005) Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo

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Preparation and characterization of D-CuP 24 mM D-P solution and 24 mM CuSO 4 solution were mixed in equal volumes (the D-P: Cu 2+ ratio was 1:0.5) and stirred overnight at room temperature to obtain 12 mM D-CuP solution

Fluid accumulation Temporary pockets of fluid (or seromas) can form under the skin