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In fact, there is a significant inverse linear correlation between riboflavin intake and MDA, a lipid peroxide, as found in a Moscow-based cross-sectional study ( Figure 1 First, glutathione is a major endogenous antioxidant against oxidative stress and lipid peroxidation

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Importantly, this implies that FSP1 may be essential not only in cancer resistance to ferroptosis but also in physiological contexts such as adipose tissue metabolism, where regulation of neutral lipid oxidation is critical for maintaining tissue homeostasis

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