This research provides additional evidence to suggest that discontinuing GLP-1 agonists at least 14 days before total joint replacement surgery is optimal to reduce the risk of delayed emergence from anesthesia, aspiration events, aspiration pneumonitis ,and conversion to intubation, said study author John R
However, when fatty acid delivery exceeds mitochondrial oxidative and redox-buffering capacity, increased electron transport pressure can elevate reactive oxygen species (ROS) production, promote endoplasmic reticulum stress, and increase susceptibility to lipid peroxidation [54, 61,62,63]
Stress triggers the release of cortisol, which in turn reduces the production of GLP-1
Key Takeaways 1
A review by Alorfi et al
Patients taking Ozempic, Wegovy, Mounjaro, and similar medications have reported experiencing dry mouth, increased tooth sensitivity, rapid tooth decay, gum disease, bad breath, enamel erosion, and in severe cases, tooth fractures or loss