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7 STEP 4 evaluated semaglutide 2.4 mg in 902 participants, all of whom received the drug for 20 weeks and then were randomized to either placebo or semaglutide for an additional 48 weeks

It's similar to how someone with high blood pressure might need to continue taking antihypertensive medications long-term

International Journal of Clinical Pharmacology and Therapeutics, 52 (10), 842849

[4] Yuan, C., Chen, D., & Wang, S

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In the OA group, morphological structure of articular cartilage showed significant destruction, including cartilage erosion, proteoglycan and cellular loss, compared with control group