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2 New classes of medications, such as the dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and sodium-glucose cotransporter- 2 (SGLT-2) inhibitors, specifically target some of the more recently identified defects described in the ominous octet to help manage uncontrolled hyperglycemia

Instead of being bound to resin, the non-side-chain carboxyl functionality of the amino acid in the peptide fragment is protected as a bulky ester

Work with your provider to determine the best management strategy based on the severity of your symptoms and the benefit you are receiving from the medication

Stopping abruptly can lead to weight regain

Do you have cardiovascular risk factors where tracking improvements would influence other treatment decisions

External reviews are particularly valuable because the independent reviewers often apply clinical guidelines more broadly than insurance companies do