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This prolonged exposure can lead to increased oxidative stress and cellular damage

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In the SURPASS clinical trial program evaluating patients with type 2 diabetes, tirzepatide demonstrated HbA1c reductions of 1.9-2.4% from baseline, with higher doses producing greater effects

These include symptoms of pancreatitis (severe abdominal pain radiating to the back, persistent vomiting), allergic reactions (difficulty breathing, facial swelling, severe rash), or signs of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness)

Here is what each group achieved at 48 weeks

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