However, full-thickness tears where the tendon has completely detached from bone typically require surgical reattachment
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Adding supplemental vitamin C in the form of ascorbic acid, the equivalent form of vitamin C found naturally in foods, will increase blood levels further, but natural absorption of vitamin C above the intake of about 200 mg decreases sharply with increasing doses by as much as 50%
Indeed, the aerobic metabolic profile (available only with the 3 antioxidant molecules) was different from the anaerobic metabolic profile, which was confirmed by analysis of polar metabolites
In addition, we used the following genetically engineered mouse strains from the Jackson Laboratory: Rosa26 mT/mG (RRID:IMSR_JAX:007676) 83 , Rosa26 M2rtTA /TetO-H2BGFP mice 84 , doubly transgenic for a reverse tetracycline-controlled transactivator (rtTA-M2) targeted to the Rosa26 locus and a HIST1H2BJ/EGFP fusion protein (H2BGFP) expressed from a tetracycline promoter element (RRID:IMSR_JAX:005104) 24,85 , multicolor reporter line Rosa26 tm1(CAG-Brainbow2.1)Cle ( R26-confetti , RRID:IMSR_JAX:017492) 86 Rosa26 flYFP/flYFP mice (R26-YFP, RRID:IMSR_JAX:006148) 87 , Rosa26 nT/nG (RRID:IMSR_JAX:023035), Nfe2l2 tm1Ywk (RRID:IMSR_JAX:017009), Rosa26 Cas9-P2A-EGFP (RRID:IMSR_JAX:024858) 63 , Notch1 fl/fl (RRID:IMSR_JAX:007181) 88 , LSL Kras +/ G12D (RRID:IMSR_JAX:019104) 83 and Rosa26 flDNM-GFP/wt (RRID:IMSR_JAX:032613 R26-DNM ) 60,89
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