Hyperinsulinism as the culprit: surgery provides the evidence
Laeger T, Baumeier C, Wilhelmi I, Wurfel J, Kamitz A, Schurmann A (2017) FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes
Are disturbances in lipid-protein interactions by Phospholipase-A2 a predisposing factor in affective illness Biol Psychiatry 1989
Understanding these contraindications is crucial for patient safety and informed decision-making
These medications mimic the bodys natural glucagon-like peptide-1 (GLP-1) hormone, which slows digestion, reduces hunger, and supports insulin regulation
Source: Barrett, et al JAMA Surgery, September 17, 2025 Researchers correlated insurance claims data and electronic medical records in a system that owns both an insurance plan (Highmark) and a provider system (Allegheny Health), and compared total medical expense for over 30,000 individuals who had either metabolic and bariatric surgery (sleeve gastrectomy) or were treated with GLP-1 medications between 2018 and 2023
