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Brain food intake & body weight Liver gluconeogenesis & steatosis Muscle glucose uptake & metabolic flexibility Adipose inflammation, insulin sensitivity Preclinical results (mouse model) vs GLP-1/GIP alone: Greater body weight reduction Stronger blood glucose lowering Better insulin sensitivity Less hepatic glucose production BUT not ready for clinic: Early preclinical stage only Human safety unknown PPAR agonism has mixed CV/renal history If it translates to humans, this could redefine metabolic disease treatment beyond anything we have today
10.3389/fpsyt.2020.00664 94 TakashimaS.TanakaF.KawaguchiY.UsuiY.FujimotoK.NadataniY.et al (2020)
Most notably, GlucoVantage dihydroberberine increased GLP-1 levels by 95% compared to the high-fat diet control group
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