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In rare cases, it can also cause serious cardiovascular side effects, including heart attack, stroke, and sudden cardiac death (heart suddenly stops beating)
PMID 21716120
IET Nanobiotechnol
DAMPs also impact Kupffer cells, activating the nucleotide-binding oligomerization domain-like receptor (NLR) Family, Pyrin Domain-Containing 3 protein (NLRP3), a type of inflammasome leading to IL-1 secretion and inflammation, and pyroptosis, releasing more DAMPs and perpetuating a destructive cycle (Peiseler et al., 2022)
Therapeutic approaches that target systemic inflammation hold great promise in protecting the BBB and mitigating cognitive decline (Yu et al., 2024)