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Therefore, it seems that the reduction of serum CRP levels in affected patients can probably be promising in reducing some complications of the disease, such as cardiovascular risks

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Trebananib (AMG 386) is a selective Ang-1/2-neutralizing peptibody and is the first drug to target the Angs/Tie-2 signaling pathway (Neal and Wakelee, 2010)

There are also questions about more serious risks, including blood clot concerns and pancreatic issues, though these remain rare