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Biomarker Verification To verify target engagement in humans without direct hippocampal transcriptomics, peripheral proxy markers must be monitored: For Intranasal GHK-Cu (Metabolic Dampening): Monitor systemic proxies for mTOR suppression and mitochondrial load

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To figure out what was blocking it, they looked for proteins that were being generated in higher numbers than normal in the cell that might be jamming up the works of the apoptosis mechanisms

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